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Forlan will team up with current world No. 101 Federico Coria of Argentina in the main draw at the clay court Challenger Tour event in Montevideo after being given a wild card.
The 37-year-old, who has 142 caps for his country, made his international debut in 2007.
Rodrigo Bentancur was banned for four games, while Ronald Araujo, Jose Maria Gimenez, and Mathias Olivera each received three-game suspensions.
The 27-year-old had been undergoing medical treatment since collapsing during Nacional's game against Brazilian side Sao Paulo on August 22.
Canada's Ismael Kone had a tame spot-kick saved by goalkeeper Sergio Rochet and Alphonso Davies hit the crossbar.
The semifinal in Charlotte, North Carolina, ended with Uruguayan players confronting Colombian fans in the stands as security personnel struggled to restore order.
Marcelo Bielsa's Uruguay were reduced to 10 men in the second half but kept Brazil at bay in regulation time before beating them 4-2 on penalties to advance to the semifinals where they will play Colombia.
Uruguay, who finished the game with 10 men after Nahitan Nandez was sent off in the 74th minute, will face Colombia in the last four.
Vinicius Jr is suspended for accumulating yellow cards.
Panama, playing in only their second Copa America, reached the knockout stage for the first time.
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