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The Mallorcan, who played on four Davis Cup-winning teams for Spain, was tearful as the national anthem was played before the tie.
The 38-year-old Spaniard has won 22 Grand Slam titles.
From next season, seven of the nine ATP Masters 1000 events will be held across 12 days.
Bolelli and Vavassori, the fourth seeds, dominated from the outset.
Sinner, Zverev, four-time Grand Slam winner Carlos Alcaraz, former US Open champion Daniil Medvedev and American Taylor Fritz have booked their spots at the ATP Finals.
The third seed, Zverev produced 15 winners and nine unforced errors, compared to 12 and 25, respectively, for Humbert.
The season-ending tournament will be held at Turin from November 10-17.
The Pickleball World Rankings is being held at RK Khanna Tennis Stadium.
Forlan will team up with current world No. 101 Federico Coria of Argentina in the main draw at the clay court Challenger Tour event in Montevideo after being given a wild card.
Sabalenka has enjoyed a spectacular season, defending her Australian Open title in January and adding the US Open trophy to her cabinet last month, as well as enjoying victories in Cincinnati and Wuhan.
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