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One of the arrested individuals is a woman named Serena, who is believed to be part of an interstate sex trafficking network.
The kidney donors were people from lower-income groups and they made the donation in lieu of money.
Two of the accused are from Haryana while the other two are natives of Delhi and Bihar.
According to the woman, her husband suffers multiple health issues following his own kidney donation.
Sabith Nassar, an agent in police custody confessed that he trafficked around 20 people to Iran for organ trade.
Sabith Nasar, a native of Edamuttom in Thrissur, reportedly took people abroad for kidney transplants between January 2019 and May 2024.
CBI says it has proof for 35 instances of victims being sent abroad illegally.
Among the 303 passengers onboard, of whom the majority were Indians, 25 persons, including two minors, expressed the wish to apply for asylum and are still on French soil.
The plane was expected to take off again on Monday morning. Its destination is not yet known. It could travel to India, where the passengers are from, to Nicaragua, its original destination, or Dubai, from where it took off.
A team of the India embassy in France has reached the passengers.