New York: Novak Djokovic's quest for a record 25th Grand Slam title ended at the US Open on Friday as the defending champion was sent packing from the third round by Australian Alexei Popyrin, while Coco Gauff overcame a big scare to advance.

Djokovic searched in vain for the form that helped him win the Paris Olympics gold medal this month, as the 37-year-old Serbian crashed 6-4, 6-4, 2-6, 6-4 to ensure he will end the year without a major for the first time since 2017.

A second stunning result in as many days at the year's final Grand Slam, following Carlos Alcaraz's exit, will encourage a host of players bidding for a rare shot at glory.

Alexei Popyrin makes a return to Novak Djokovic. Photo: USA TODAY Sports/Robert Deutsch via Reuters
Alexei Popyrin makes a return to Novak Djokovic. Photo: USA TODAY Sports/Robert Deutsch via Reuters

Frances Tiafoe kept alive his hopes of becoming the first American man to claim the US Open title since Andy Roddick 21 years ago by outlasting compatriot Ben Shelton 4-6, 7-5, 6-7(5), 6-4, 6-3 to move ahead.

He was joined by another top contender in Taylor Fritz, who eased past Francisco Comesana 6-3, 6-4, 6-2 to emerge as the first American man to make the last 16 at all four Grand Slams in the same year since Andre Agassi in 2003.

"It's a pretty cool thing to do because just last year I was really struggling with Grand Slam results," Fritz said.

"So it's nice to do a lot better at something I put a lot of emphasis on, which was performing at the slams and performing at the biggest tournaments."

Coco Gauff reacts after winning a point against Elina Svitolina. Photo: USA TODAY Sports/Mike Frey via Reuters
Coco Gauff reacts after winning a point against Elina Svitolina. Photo: USA TODAY Sports/Mike Frey via Reuters
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Gauff had conceded only six games across the opening two rounds in New York, but came under immediate pressure from Elina Svitolina as she dropped the first set to the Ukrainian before rebooting to complete a 3-6, 6-3, 6-3 victory.

"I feel like I lost eight points in a row at the end of the first set. I don't really know the exact number. Probably more," world No. 3 Gauff said.

"So I knew I needed a reset at that point. I just went and used the bathroom, changed the bottom half of my clothes, and splashed some water on my face, and felt like a new person coming out.

"I just didn't want to leave the court with any regrets."

Paul Badosa was also in no mood to bow out tamely as the former world No. 2 rallied from a set down to beat Elena-Gabriela Ruse 4-6, 6-1, 7-6(8).

The Spaniard has hit top form on the American hardcourts a few months after she contemplated retirement when doctors told her she could struggle on the surface due to a back injury.

"It means so much. After what I've been through the last year, for me, it's very special to already be on this level," said Badosa, who won her first title in over two years at Washington this month.

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"At the beginning of the year I was obsessed. I wanted to do the comeback of the year no matter what.

"I think I'm in a good moment now and I'm happy that I can prove all this again and that I'm playing maybe at one of the best levels of my career."

Three-time runner-up Victoria Azarenka could not avoid an exit as the Belarusian fell to a 6-4, 3-6, 6-1 defeat against unseeded Wang Yafan.

Wang's Chinese compatriot and Olympic gold medallist Zheng Qinwen also continued her winning run by beating Jule Niemeier 6-2, 6-1, but it was the end of the road for Shang Juncheng, who squandered a two-set lead against eighth seed Casper Ruud.

Norwegian Ruud, the 2022 runner-up, won 6-7(1), 3-6, 6-0, 6-3, 6-1 and credited his mental toughness for getting him through.

"We're all physically strong out here. It's a matter of having the right mindset and believing all the way. Luckily I wasn't down in the third set," Ruud said.

"That third set probably I got some fire going and just kept believing."

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