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The India vice-captian reached 1,602 runs after a brilliant 91 against West Indies in Vadodara.
The India vice-captain scored a century in the third ODI against Australia.
India lost by 83 runs with Ashleigh Gardner claiming a fifer and hitting a fifty.
India and Australia will play the third women's ODI in Perth on Wednesday.
The Uttarakhand batter is the youngest India to score a double century in a List A match.
India won by 6 wickets with Mandhana top scoring with 100 and captain Harmanpreet making an unbeaten 70.
Visitors kept losing wickets at regular intervals.
India have moved into second position in the points table with a positive net run rate.
Harmanpreet Kaur will lead a 15-member Indian squad.
Shafali scored a 48-ball 81 as India posted 178/3 before beating Nepal by 82 runs.
Results 1-10 of 72