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The tobacco products were packed in more than ten large sacs and concealed under a tarpaulin inside a lorry.
According to police, this is the fifth MDMA seizure in July.
The male and female passengers had 1.9 kg and 1.3 kg on cocaine respectively in their stomachs.
A Malayali named Safeer was also taken into custody from Ernakulam North railway station on Tuesday night.
Land, bikes and cars which were registered in the name of the accused and also in the name of immediate relatives have been seized by the police.
The police seized 17 MDMA tablets and cocaine from the scene
The 30-year-old was arrested in a joint operation by DANSAF and the Kayamkulam Police.
Four persons have been arrested so far in connection with the case.
The officials reportedly confiscated the drugs worth crores after encircling the two cars on the National Highway 544.
100 grams of Methamphetamine was confiscated from a trio that had smuggled the drug from Andhra-Odisha border.
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