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Arsenal were held 1-1 by Brighton after Declan Rice was sent off.
Manchester City scored three times in less than four minutes after conceding a shock early goal to crush Ipswich and remain perfect in their quest for a fifth consecutive league title.
Chelsea, in their first Premier League outing under new manager Enzo Maresca, were largely outclassed by their more composed visitors.
The result also meant Aston Villa have qualified for Champions League for the first time since the 1982-83.
The shortlist for the women's best player includes two 2023 World Cup champions, Aitana Bonmati and Jennifer Hermoso from Spain, alongside Linda Caicedo, who represents Colombia.
Trent Alexander-Arnold drilled in an 80th-minute equaliser with his right foot to deny City a 24th successive home win in all competitions.
City thoroughly dominated shell-shocked United in the second half.
Manchester United tasted a 1-3 defeat at Old Trafford while City won by the same margin against the Hammers.
In all, referee Anthony Taylor doled out 11 yellow cards along with Rodri's red, with seven of the yellows coming in a bad-tempered second half as Forest tried to leverage their extra man, but to no avail.
City were crowned European champions for the first time and they also secured the treble of Premier League, FA Cup and Champions League, with Guardiola becoming the first men's manager in history to achieve the feat on more than one occasion.
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