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Leeds defender Rasmus Kristensen's second-half equaliser denied Newcastle the victory that would have all but assured them a place in next season's Champions League.
The result moved Arsenal to 28 points from 11 games, two ahead of second-placed Manchester City, while Southampton are 15th with 12 points from 12 games.
Timo Werner and Mason Mount scored two goals each in the 6-0 win.
Diogo Jota's early double set Liverpool on their way to a crushing 4-0 victory over Southampton on Saturday to move up to second in the Premier League standings. The Portuguese forward steered home Andrew Robertson's cutback to open the scoring after 97 seconds, before another simple finish
Timo Werner, Trevor Chalobah and Ben Chilwell scored for the Blues.
India and New Zealand will battle it out for the prestigious title at Southampton on June 18.
United became only the second team to win a Premier League game 9-0, matching their 9-0 win over Ipswich Town in 1995 and also Leicester City's away rout of Southampton in 2019.
A superb second-minute lob by Danny Ings gave Southampton a surprise 1-0 home win over leaders Liverpool.
outhampton beat Premier League leaders Everton 2-0 at St Mary's Stadium as Carlo Ancelotti's side became the final club to lose a game this season.
On the day that second-placed Manchester City's two-year ban from European football was overturned on appeal, meaning only the top four will qualify for the Champions League as usual, United's late lapse left them fifth on 59 points.