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Badosa wrote on social media Sunday that the pair decided to amicably part ways after being a couple since last year.
Ninth seed Kviotova brushed aside the challenge of Belarusian Aliaksandra Sasnovich.
Swiatek reached her first Indian Wells final after overpowering former champion Simona Halep 7-6(6), 6-4.
In their first career meeting, Muguruza's superior firepower put Badosa on the back foot from the outset.
Karolina Pliskova missed the cut despite her comeback victory over Barbora Krejcikova.
Sabalenka fought back from a set down to beat Swiatek 2-6, 6-2, 7-5 in another match.
Results 1-6
