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Standing 2.11m tall, Karlovic's huge serves and unorthodox style caused problems for some of the sport's biggest names and he won two of his three meetings with world No, 1 Novak Djokovic.
The Indian qualifier fought hard before losing 3-6, 6-7(4) to the tall Croat, who fired 16 aces in the one hour and 13-minute contest.
Results 1-2