Two B2 stealth bombers belonging to the US Air Force struck Islamic State camps in Libya reported the Washington post.
The attack comes less than a month after pentagon declared an end to the extended air campaign.
The operation was approved by outgoing president Barack Obama, said Pentagon press secretary, Peter Cook.
The aircraft dropped over a 100 bombs and hit two IS camps southwest of Sirte, according to Cook.
US defense secretary Ashton B Carter told reporters that the attack was 'critically important' in dealing with the IS threat.
After initial bombarding by the two B-2s, MQ-9 armed drones used Hellfire missiles to hit the remaining targets.
The US government has launched over 500 airstrikes against the IS fighters under Operation Odyssey Lightning.